Structural and mechanistic studies of VPS4 proteins
نویسندگان
چکیده
منابع مشابه
Structural and mechanistic studies of VPS4 proteins.
VPS4 ATPases function in multivesicular body formation and in HIV-1 budding. Here, we report the crystal structure of monomeric apo human VPS4B/SKD1 (hVPS4B), which is composed of five distinct elements: a poorly ordered N-terminal MIT domain that binds ESCRT-III substrates, large (mixed alpha/beta) and small (alpha) AAA ATPase domains that closely resemble analogous domains in the p97 D1 ATPas...
متن کاملBiochemical and structural studies of yeast Vps4 oligomerization.
The ESCRT (endosomal sorting complexes required for transport) pathway functions in vesicle formation at the multivesicular body, the budding of enveloped RNA viruses such as HIV-1, and the final abscission stage of cytokinesis. As the only known enzyme in the ESCRT pathway, the AAA ATPase (ATPase associated with diverse cellular activities) Vps4 provides the energy required for multiple rounds...
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Structural and mechanistic studies of enolase.
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متن کاملStructural and mechanistic aspects of Amt/Rh proteins.
Amt/Rh proteins, which mediate movement of ammonium across cell membranes, are spread throughout the three kingdoms of life. Most functional studies on various members of the family have been performed using cellular assays in heterologous expression systems, which are, however, not very well suited for detailed mechanistic studies. Although now generally considered to be ammonia conducting cha...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2005
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600818